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Mark is the Director of the PHG Foundation, a health policy unit at the University of Cambridge with a particular interest in the implementation of genomics and associated technologies into healthcare. He joined the Foundation in 2012 as Programme Director and was appointed Director in October 2017. Mark graduated in medicine from the University of Edinburgh in 1992 and trained in general practice. Following a post as District Medical Officer in the Caribbean, he returned to the UK to train in public health medicine. Appointed NHS Consultant in Public Health Medicine in 2005, his special interests include healthcare public health, the evaluation of diagnostics and the commissioning of clinical genetics services.

He has been a standing member of the Diagnostics Advisory Committee (DAC) of the National Institute for Health and Care Excellence (NICE) (2010-2022) and the Chair of the DAC (2017-2022). Mark has also held the following appointments: public health advisor to the NHS UK Genetic Testing Network (UKGTN) (2006-2018), member of the Council of the Royal College of Physicians of Edinburgh and the Board of the Faculty of Public Health (2017 -2021). He is an accredited clinical supervisor for the HEE East of England Public Health Training Programme.